Title: Orangeburg County Vacation Packages 2026 from $841 | Expedia.com [Orangeburg County Travel Guide](https://expedia.com/Orangeburg-County.dx553248635996998003)[Orangeburg County Hotels](https://expedia.com/Destinations-In-Orangeburg-County.d553248635996998003.Hotel-Destinations)[Vacation Rentals in Orangeburg County](https://expedia.com/Destinations-In-Orangeburg-County.d553248635996998003.Vacation-Rental-Destinations)[Orangeburg County Flights](https://expedia.com/Destinations-In-Orangeburg-County.d553248635996998003.Flight-Destinations)[Car Rentals in Orangeburg County](https://expedia.com/Destinations-In-Orangeburg-County.d553248635996998003.Car-Rental-Destinations) ![](https://images.trvl-media.com/place/9953/a26d5a16-8cd2-405d-94ab-122a2f63e661.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Orangeburg County Vacations & Trips from $841 ## Book a Hotel + Flight or Car together to unlock savings - ## Plan, book, travel with confidence - ### Better together Save up to $1,045 when you book a flight and hotel together\* - ### Find the right fit With over 300,000 hotels worldwide, it's easy to create a perfect package - ### Rest easy Plan, book, and manage your trip all in one place ### Your Orangeburg County Vacation Reserve a vacation package to Orangeburg County and make planning your getaway quick and easy. With all the logistics organized before you leave, you can focus on enjoying every second in this interesting destination. With so much to do and see on a trip to Orangeburg County, it can be difficult to know where to start. Kick off your journey in [Santee](https://www.expedia.com/Santee.d9953.Destination-Travel-Guides) at Santee State Park and Santee Cooper Country Club — two much-loved attractions here. Another great city worth adding to your itinerary is [Orangeburg](https://www.expedia.com/Orangeburg.d6058108.Destination-Travel-Guides). Be sure not to miss Edisto Memorial Gardens and Smith-Hammond-Middleton Memorial Center. Whether you plan to travel for a couple of days or a couple of weeks, Expedia are here to help you customize your next Orangeburg County vacation. ## Top destinations in Orangeburg County ![Santee River Dam on Lake Marion, South Carolina, Aerial drone view of electric power lines](https://images.trvl-media.com/place/9953/712fb946-715a-4a74-8bf7-2c2bbd891023.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Santee [](https://expedia.com/Santee.d9953.Destination-Travel-Guides) ![Cypress Trees with Spanish Moss growing on them. In Lake Marion at Santee State Park, Santee, Orangeburg County, South Carolina](https://images.trvl-media.com/place/6058108/7d590932-d0d2-48e4-90bf-23f9acc0734e.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Orangeburg [](https://expedia.com/Orangeburg.d6058108.Destination-Travel-Guides) ![Eutawville, South Carolina sunset near Lake Marion with empty hammock on pine trees overlooking water landscape view at Fountain lake in spring evening with nobody](https://images.trvl-media.com/place/3000455924/dc128f90-2885-4acb-80b5-581201528ba2.jpg?impolicy=fcrop&w=384&h=216&q=medium) #### Eutawville [](https://expedia.com/Eutawville.d3000455924.Destination-Travel-Guides) ## The Latest Orangeburg County Vacation Packages Price found within the past 48 hours. Click for updated prices. ![Emeline](https://images.trvl-media.com/lodging/1000000/10000/8900/8890/02b86b23_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Emeline Charleston Historic District Save 100% on your flight $841 per person May 19 - May 22 found 1 day ago Roundtrip flight included Boston (BOS) to Charleston (CHS) 9.4/10 Exceptional! (1,680 reviews) The coffee nook was well maintained. We enjoyed making a quick cup of coffee every morning before starting the day. Reviewed on Apr 3, 2026 ![Haven by Avantstay Luxury Beachfront Home w/ Pool & Gorgeous Patios](https://images.trvl-media.com/lodging/85000000/84030000/84023500/84023462/99557bea_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### Haven by Avantstay Luxury Beachfront Home w/ Pool & Gorgeous Patios Save 100% on your flight $12,048 per person Jun 27 - Jul 5 found 1 day ago Roundtrip flight included New York (NYC) to Charleston (CHS) No reviews ![502 Ocean Blvd by Avantstay Beachfront w/ Pool & Ocean Views!](https://images.trvl-media.com/lodging/96000000/95330000/95327400/95327324/a80e96f2_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### 502 Ocean Blvd by Avantstay Beachfront w/ Pool & Ocean Views! Ocean Boulevard Save 100% on your flight $6,381 per person May 17 - May 22 found 1 day ago Roundtrip flight included New York (LGA) to Charleston (CHS) No reviews ![4 36th Avenue by Avantstay Chef's Kitchen, Rooftop & Pool!](https://images.trvl-media.com/lodging/92000000/91600000/91597000/91596947/109a3a53_y.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) ### 4 36th Avenue by Avantstay Chef's Kitchen, Rooftop & Pool! Save 100% on your flight $6,852 per person May 21 - May 26 found 22 hours ago Roundtrip flight included Philadelphia (PHL) to Charleston (CHS) No reviews ## Find the Best Orangeburg County Vacation Packages ## Orangeburg County Essential Information | Language | English | | --------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Currency | U.S dollars | | Closest Airport | Columbia Metropolitan Airport (CAE) | | Top Sights | [Santee State Park](https://www.expedia.com/Santee-State-Park-Santee.d6140632.Vacation-Attraction), [Edisto Memorial Gardens](https://www.expedia.com/Edisto-Memorial-Gardens-Orangeburg.d553248621532654892.Vacation-Attraction) and [Santee State Park](https://www.expedia.com/Santee-State-Park-Santee.d6140632.Vacation-Attraction) | ## Orangeburg County Hotel Deals ![Baymont by Wyndham Santee](https://images.trvl-media.com/lodging/1000000/20000/15400/15379/1987eeb3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Baymont by Wyndham Santee 249 Britain Street Santee SC Fully refundableReserve now, pay when you stay $80 nightly $89 total Apr 9 - Apr 10 Total with taxes and fees 7.8/10 Good! (1,434 reviews) If you're looking for a decent breakfast, this is not the place for you. Room was quiet and fairly clean, but otherwise not an impressive property. Reviewed on Apr 6, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F9%2F2026&endDate=4%2F10%2F2026&selected=15379&PinnedHotelID=15379&HadPinnedHotel=true®ionId=553248635996998003) ![Tru By Hilton Santee](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Tru By Hilton Santee 263 Britain St. and 273 Britain St. Santee SC Fully refundableReserve now, pay when you stay $113 nightly $125 total May 4 - May 5 Total with taxes and fees 9.2/10 Wonderful! (786 reviews) Clean and quiet and a really nice hotel. Breakfast was super. Reviewed on Apr 6, 2026 [](https://expedia.com/Hotel-Search?startDate=5%2F4%2F2026&endDate=5%2F5%2F2026&selected=92600969&PinnedHotelID=92600969&HadPinnedHotel=true®ionId=553248635996998003) ![Best Western Plus Santee Inn](https://images.trvl-media.com/lodging/1000000/30000/21900/21863/93ba5eb3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Best Western Plus Santee Inn I 95 Exit 98 Santee SC Fully refundableReserve now, pay when you stay $119 nightly $132 total Apr 15 - Apr 16 Total with taxes and fees 8.8/10 Excellent! (1,000 reviews) Very clean! Staff was amazing! Reviewed on Apr 6, 2026 [](https://expedia.com/Hotel-Search?startDate=4%2F15%2F2026&endDate=4%2F16%2F2026&selected=21863&PinnedHotelID=21863&HadPinnedHotel=true®ionId=553248635996998003) [See all 630 properties in Orangeburg County](https://expedia.com/Hotel-Search?rfrrid=TG.LP.Hotels.Package&startDate=4%2F9%2F2026&endDate=4%2F10%2F2026®ionId=553248635996998003) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/all-inclusive_holidays_US.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) All Inclusive Vacations [](https://expedia.com/lp/theme-vacations/all-inclusive-vacations?rfrr=editorial.All_Inclusive%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/10/17/XPC_Beach_Overview_HR_v3.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Beach Vacations [](https://expedia.com/lp/theme-vacations/beach-vacations?rfrr=editorial.Beach_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/06/08/Family_holidays_US_3_.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Kid Friendly Vacations [](https://expedia.com/lp/theme-vacations/kid-friendly-vacations?rfrr=editorial.Kid_Friendly%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2022/04/29/frCA_Sejours_golf-Portugal.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Golf 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[](https://expedia.com/lp/theme-vacations/honeymoon-vacations?rfrr=editorial.Honeymoon_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/Mountain-vacations.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Mountain Vacations [](https://expedia.com/lp/theme-vacations/mountain-vacations?rfrr=editorial.Mountain_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/fishing-vacations-2.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Fishing Vacations [](https://expedia.com/lp/theme-vacations/fishing-vacations?rfrr=editorial.Fishing_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2019/05/16/Hyatt%20Zilara%20Cancun%20-%20All%20Inclusive%20-%20Adults%20Only.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Adults Only Vacations [](https://expedia.com/lp/theme-vacations/adults-only-vacations?rfrr=editorial.Adults_Only%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/23/waterpark-vacations.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Waterpark Vacations [](https://expedia.com/lp/theme-vacations/waterpark-vacations?rfrr=editorial.Waterpark_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/Caribean_scuba_diving.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Scuba Diving Vacations [](https://expedia.com/lp/theme-vacations/scuba-diving-vacations?rfrr=editorial.Scuba_Diving%20Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/05/08/aruba_yoga.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Yoga Vacations [](https://expedia.com/lp/theme-vacations/yoga-vacations?rfrr=editorial.Yoga_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2023/04/04/EPS-RBC-SummerBeachVacations-AdobeStock_206356322.jpeg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Cheap Vacations [](https://expedia.com/lp/theme-vacations/cheap-vacations?rfrr=editorial.Cheap_Vacations.click) ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/06/26/1175883311.jpg?impolicy=fcrop&w=300&h=300&q=mediumHigh) Solo Vacations [](https://expedia.com/lp/b/vacations/solo-vacations?rfrr=editorial.Solo_Vacations.click) Explore a world of travel with Expedia ## Other vacations you might like - Top cities in Orangeburg County - Vacations and getaways similar to Orangeburg County - Best vacation destinations by month - [Santee Vacations ](https://expedia.com/Santee.d9953.Destination-Travel-Guides) - [Orangeburg Vacations ](https://expedia.com/Orangeburg.d6058108.Destination-Travel-Guides) - [Eutawville Vacations ](https://expedia.com/Eutawville.d3000455924.Destination-Travel-Guides) - [Neeses Vacations ](https://expedia.com/Neeses.d3000456036.Destination-Travel-Guides) - [Cope Vacations ](https://expedia.com/Cope.d3000455896.Destination-Travel-Guides) - [Rowesville Vacations 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](https://www.expedia.com/lp/b/where-to-go/vacations-september) - [October Vacations and Deals ](https://www.expedia.com/lp/b/where-to-go/vacations-october) - [November Vacations and Deals ](https://www.expedia.com/lp/b/where-to-go/vacations-november) - [December Vacations and Deals ](https://www.expedia.com/lp/b/where-to-go/vacations-december) \* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save even more - get up to 20% on select hotels when you book on the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app